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Ulthera Prime

“Reignite your youthful energy with the precision of Prime”

What Is Ulthera Prime? How Is It Different from Regular Ulthera, and Who Is It For?

Introduction: Why “Prime” Matters

Ulthera Prime is the latest platform upgrade of Ultherapy® (MFU-V: Microfocused Ultrasound with real-time Visualization) — the only ultrasound lifting device cleared by the US FDA with real-time imaging. This new generation improves both hardware and software to deliver ~20% faster treatments, a ~35% larger screen with clearer and wider ultrasound images, and smoother workflow for physicians and patients alike. The result: more precise treatment, greater comfort, and the same proven lifting results backed by clinical research .

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เครื่อง Ulthera Prime scaled
เครื่อง Ulthera Prime 3
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What Is Ulthera / Ultherapy® ?

Ultherapy® uses Microfocused Ultrasound with real-time Visualization (MFU-V) to deliver precise thermal coagulation points (TCPs) at controlled depths — from the deep dermis down to the SMAS/platysma layer — without damaging the skin surface. These thermal points trigger the body’s natural wound-healing cascade, stimulating neocollagenesis and neoelastogenesis for a natural lift and tightening effect over time.

The real-time ultrasound imaging allows the practitioner to see-plan-treat: visualize target tissue layers (up to ~8 mm deep) before each shot, ensuring precise energy placement and minimizing off-target delivery .

FDA-cleared treatment areas: brow lift, submental/neck lift, and décolleté wrinkle improvement — with results that continue to improve over 3–6 months and typically last ~1 year or more, depending on individual factors .

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How Ulthera Prime Improves on the Original: Precision Power Prime

Ulthera Prime maintains the proven MFU-V core technology but upgrades the device for enhanced precision, efficiency, and user experience.

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In short: Same core science (MFU-V), better tools. Sharper, wider imaging and faster system performance allow more consistent and confident shot placement, reducing total chair time.

Key Enhancements

~20% faster treatment time

on average, without compromising lifting efficacy

~35% larger display

with higher refresh rate, improved clarity, brightness, and 2× wider field of view, allowing more confident targeting of tissue layers

Optimized workflow & ergonomics

smoother scanning, improved transducer grip comfort, quieter operation, and faster system booting

Unique to Ulthera Prime

still the only ultrasound lifting device with FDA-cleared real-time visualization

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Lifting Mechanism: From TCPs to New Collagen

  1. Immediate phase: MFU energy heats focal points to 60–70 °C, causing immediate collagen contraction for subtle instant tightening.
  2. Remodeling phase (weeks–months): The wound-healing process stimulates new collagen/elastin formation around TCPs, improving skin elasticity and firmness. The most visible lifting typically occurs between 3–6 months and can persist for 12+ months .

Clinical Evidence for MFU-V / Ultherapy®

  • Systematic Review & Meta-analysis (ASJ, 2025): 42 studies showed a mean “improved” rating by physicians in 89% of cases, patient satisfaction ~84%, and an excellent safety profile. Common transient effects: erythema, edema, tenderness, bruising; mean pain score ~4.9/10 .
  • Pan-Asian Consensus (JCAD, 2021): Highlighted real-time visualization as critical for accuracy and consistency, since target depth varies by age, sex, BMI, and facial region. Direct visualization reduces off-target delivery and avoids critical structures .
  • Foundational studies (2007–2014) confirmed MFU’s ability to target SMAS and achieve brow/neck/jawline lifting without surgery (Alam 2010; Fabi & Goldman 2014; White 2007) .
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เครื่อง Ulthera Prime 2
เครื่อง Ulthera Prime 3

Ulthera Prime vs Ulthera (รุ่นเดิม): เทียบทีละประเด็น

สอบถามวิธีที่เหมาะกับตัวเอง
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Feature Ulthera (Original) Ulthera Prime (New)
Treatment speed
Standard

~20% faster per case

Visualization
Standard real-time ultrasound

~35% larger display, 2×

wider field, sharper/brighter imaging, reduced noise

User workflow
Standard ergonomics

Enhanced ergonomics, quieter operation, smoother scanning, faster boot

Core principle
MFU‑V + DeepSEE®

Same MFU-V but with better planning & monitoring

tools for more consistent shot placement
เครื่อง Ulthera Prime 2
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Who Is Ulthera Prime For?

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Mild to moderate skin laxity: brows, jawline, under-chin, neck, décolleté

Those seeking natural-looking results without downtime

Previous Ultherapy® patients who want faster sessions and clearer imaging

Patients considering non-surgical maintenance before or alongside injectables/biostimulators

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Treatment Areas & Expected Results

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Timeline: Noticeable changes within weeks → peak results at 3–6 months → maintenance for ~1 year+ .

Brow/Forehead

subtle brow elevation, refreshed look

Jawline/Under-chin

improved definition with proper vector mapping

Neck

reduction of sagging and horizontal lines

Décolleté

softened fine lines

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Safety & Adverse Effects

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Over 3 million treatments worldwide, supported by 120+ peer-reviewed papers / 56 studies

Common transient effects: redness, swelling, tenderness, bruising, numbness/tingling; rare effects include burns/blisters or temporary nerve effects — typically resolving spontaneously

2025 meta-analysis confirmed overall safety with mostly mild/moderate, self-limiting adverse events .

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Comparison to HIFU, RF, and Lasers

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MFU-V (Ultherapy®) is the only one with real-time visualization — the physician can “see-and-shoot” the exact tissue layer, ensuring precise energy delivery .

RF and lasers are effective in more superficial skin layers but do not reach the SMAS like MFU-V. Many patients benefit from combination protocols designed by a qualified dermatologist .

What to Expect During Treatment (See–Plan–Treat)

1.Consult & Scan

Clinical assessment + ultrasound scan to measure skin/fat/SMAS thickness

2.Plan

Select 1.5 / 3.0 / 4.5 mm depths and lifting vectors based on your unique anatomy

3.Treat

Deliver shots along planned lines — density adjusted for tissue needs, not fixed numbers

4.After

Resume normal activities; mild redness/tenderness is possible; follow skincare & sun protection advice

Technical note: Ulthera Prime transducers provide imaging up to ~8 mm deep and treat lengths up to ~25 mm per line (depending on model) .

Why Ulthera Prime at 22 Square Clinic?

Because we believe in “Precision First” — letting Prime’s advanced technology work to its fullest:

  • Dermatologist-performed: every case guided by real-time imaging
  • Prime Protocol™: Prime-Mapping of lifting vectors + depth/energy tailored to your anatomy
  • Pain & Comfort Care: optimized anesthesia & pacing to minimize discomfort
  • Total Face Strategy: design brow–midface–jawline–neck plan for harmonious results

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FAQ

Q1: How often is it needed? How long does it last?

A: Typically once per year. Results peak at 3–6 months and last ~1 year+, varying by individual .

Q2: Does it hurt / require downtime?

A: Expect deep “zing” sensations during shots; most return to normal activities immediately. Side effects are generally mild and self-limiting .

Q3: How is it different from HIFU?

A: Ulthera Prime has real-time visualization, allowing precise targeting of the correct layer — HIFU generally lacks this capability .

Q4: Is Prime “stronger” than the old Ulthera?

A: Same MFU-V principle and clinical effect, but 20% faster workflow and sharper, wider imaging improve accuracy and consistency .
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Quick Prep / Aftercare

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Rest well; avoid heavy alcohol 24 h pre-treatment

Mild tenderness/redness may occur for 24–48 h — OTC pain relief if needed

Avoid excessive heat/sauna for 48 h; use gentle skincare and broad-spectrum SPF daily

Attend follow-up review (typically at 3 months)

Ready to Prime your youth?

Consult the dermatology team at 22 Square Clinic for Prime-Mapping and a lifting plan 

tailored to your exact anatomy — Reignite your youth — Precision Power Prime.

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LINE: @22squareclinic
22 Square Clinic

References

  • Merz Aesthetics Press Release :

    Merz Aesthetics. Launch of Ultherapy PRIME Platform. Press release, Sept 23, 2024.

  • Ultherapy.com (Official) :

    Ultherapy.com. FDA-Cleared Indications & Technology Overview. Accessed 2025.

  • Ulthera® PRIME IFU (ฉบับอัปเดต 2024) :

    Ulthera® PRIME Instructions for Use (IFU), 2024 update.

  • JCAD 2021 (Park JY et al.) :

    Park JY et al. Customized Treatment Using MFU-V: Pan-Asian Consensus. J Clin Aesthet Dermatol. 2021.

  • ASJ 2025 Systematic Review & Meta‑analysis (Amiri M. et al.) :

    Ultherapy.com. Indications for Brow, Neck, Submental, Décolleté. Accessed 2025.

  • JAAD 2010 (Alam M. et al.) :

    Ultherapy.com. Only Ultrasound Lifting with FDA-Cleared Real-Time Imaging. Accessed 2025.

  • Dermatol Surg 2014 (Fabi SG & Goldman MP) :

    Alam M et al. Ultrasound tightening of facial and neck skin: a rater-blinded prospective cohort study. J Am Acad Dermatol. 2010;62(2):262-269.

  • Arch Facial Plast Surg 2007 (White WM et al.) :

    Amiri M et al. Efficacy and Safety of MFU-V: Systematic Review & Meta-analysis. Aesthet Surg J. 2025.

  • Systematic Review 2023 (Contini M. et al.) :

    Fabi SG, Goldman MP. Retrospective evaluation of MFU for lifting/tightening the face & neck. Dermatol Surg. 2014;40(5):569-575.

  • White WM et al.

    Selective creation of thermal injury zones in the SMAS using MFU. Arch Facial Plast Surg. 2007;9(1):22-29.

  • Contini M et al.

    Systematic Review of MFU efficacy in mild-moderate laxity. J Cosmet Dermatol. 2023.

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Reserve Your Consultation — 50% OFF

Professional advice. Personalized service.
Limited slots available for first-time clients